ONC-392注射液

目前，靶向CTLA-4的抗体药物（伊匹单抗）用于肿瘤治疗有效，但75-90%的患者存在免疫治疗相关不良反应（irAEs）。刘阳/郑盼教授实验室最新研究成果阐明了靶向CTLA-4抗体药物的抗癌效应（CITE）和irAEs的机制，并且通过抗体工程手段，成功开发能够有效地强化抗CTLA-4抗体的CITE，同时最大限度地降低irAEs的新一代靶向CTLA-4的免疫治疗产品。

目前，ONC-392注射液在中美两国均已进入一期临床研究阶段。

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